Cutting edge: evidence for a signaling partnership between urokinase receptors (CD87) and L-selectin (CD62L) in human polymorphonuclear neutrophils.

Human Polymorphonuclear Neutrophils CD87) Induces Proinflammatory Signaling in Clustering of Urokinase Receptors (uPAR;

E-selectin prefers fatty-sweet receptors on rolling neutrophils.

Selectins constitute a highly conserved family of glycoproteins that, as their lectin surname suggests, bind terminal sugars expressed on lipid and protein receptors to mediate adhesive interactions and transmembrane signaling between leukocytes, platelets, and inflamed endothelium. It has long been known that all 3 selectin family members exploit a common biochemical recognition strategy in bi...

Purinergic signaling and immune cell chemotaxis. Focus on "the UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils".

PURINERGIC RECEPTORS enable cells to detect and respond to extracellular nucleotides and adenosine. Presently, eight G protein-coupled P2Y receptors, four adenosine receptors, and seven ionotropic P2X receptors have been cloned and characterized (11). In addition, multiple ectonucleotidases and pathways for nucleotide release have been identified in mammalian cells where they function collabora...

E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils.

The selectin family of molecules (L-, P-, and E-selectin) mediates adhesive interactions between leukocytes and endothelial cells required for recruitment of leukocytes to inflammatory sites. Soluble E-selectin levels are elevated in inflammatory diseases and act to promote neutrophil beta(2)-integrin-mediated adhesion by prolonging Ca(2+) mobilization. Although soluble E-selectin alone was una...

L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts.

Previous studies reported that L-selectin (CD62L) on human peripheral blood neutrophils serves as an E-selectin ligand. This study shows that CD62L acquired E-selectin-binding activity following phorbol ester (PMA) treatment of the Jurkat T cell line and anti-CD3/IL-2-driven proliferation of human T lymphocytes in vitro. The recombinant porcine E-selectin/human Ig chimera P11.4 showed neuramini...